Tag Archives: Bactrim

Trimethoprim and Hyperkalemia

Trimethoprim and sulfamethoxazole is an antibiotic combination (Bactrim®) commonly used to treat a variety of infections. In general, such therapy is well tolerated. But trimethoprim has a property which can cause trouble. Structurally and pharmacologically it resembles amiloride. The latter is a potassium sparing diuretic that exerts its effect by blocking the Na channel along…

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