Tag Archives: diabetic nephropathy

Role of Hyperfiltration in the Pathogenesis of Diabetic Nephropathy

The following is the summary of a book chapter written by Sandra Sabatini and me in Advances in Pathogensis of Diabetic Nephropathy published by Nova. The chapter details the current state of our knowledge about globular hyperfiltration as a causal event in the glomerulosclerosis that characterizes diabetic nephropathy. The entire chapter is appended below as a pdf file. The pathogenesis of diabetic nephropathy is doubtless…

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More on Angiotensin Blockade and Diabetic Nephropathy

I recently reviewed a paper that indicated that angiotensin blockade with an angiotensin receptor blocker (ARB) did not protect against the development of diabetic nephropathy in diabetic patients with normal renal function. Despite what that paper concluded angiotensin blockade with and an angiotensin converting enzyme (ACE) inhibitor offered protection. Two papers in the July 7…

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Angiotensin Blockade and Diabetic Nephropathy

The July 2 issue of the New England Journal of Medicine has an article on the prevention of diabetic nephropathy and retinopathy that will elicit much attention. It concludes “Early blockade of the renin-angiotensin system in patients with type 1 diabetes did not slow nephropathy progression but slowed the progression of retinopathy.” An accompanying editorial…

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