Tag Archives: hyperkalemia

Trimethoprim and Hyperkalemia

Trimethoprim and sulfamethoxazole is an antibiotic combination (Bactrim®) commonly used to treat a variety of infections. In general, such therapy is well tolerated. But trimethoprim has a property which can cause trouble. Structurally and pharmacologically it resembles amiloride. The latter is a potassium sparing diuretic that exerts its effect by blocking the Na channel along…

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Is Kayexalate Safe and Effective?

Ion-Exchange Resins for the Treatment of Hyperkalemia: Are They Safe and Effective? is the title of a Clinical Commentary in this month’s Journal of the American Society of Nephrology. Kayexalate is the brand name of the commonly prescribed cation exchange resin sodium polystyrene sulfonate (SPS) used to treat hyperkalemia (high blood potassium). The drug was…

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